Association Between the IL10 j1082A9G ( rs1800896) Single- Nucleotide Polymorphism and Atopic Dermatitis: A Systematic Review and Meta- Analysis

作者：Chen Suzan; Zhao Linlu^*

来源：Dermatitis, 2013, 24(4): 161-165.

DOI：10.1097/DER.0b013e31829cb0e4

Background The potentially functionally relevant IL10 -1082A>G (rs1800896) promoter region single-nucleotide polymorphism has been implicated in the pathogenesis of atopic dermatitis (AD). Although this relationship has been studied extensively, these association studies were limited by small sample size.
Objective To increase statistical power and obtain a more precise estimate of the association, literature evidence on IL10 -1082A>G and AD was assessed by conducting a systematic review and meta-analysis.
Methods This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed (MEDLINE), EMBASE, Scopus, and HuGE Literature Finder literature databases were systematically searched for relevant studies. Summary odds ratios and corresponding 95% confidence intervals were estimated using the fixed-effect inverse variance analysis method for allelic (G vs A) and genotypic comparisons.
Results Meta-analysis of 7 studies (n = 849 cases and 1195 controls) found a nonsignificant association between the IL10 -1082A>G polymorphism and AD (allelic odds ratio, 1.02; 95% confidence interval, 0.88-1.19; P = 0.77).
Conclusions This study was unable to find a direct association between IL10 -1082A>G and AD. Further studies are needed to reveal the contributions of haplotype and gene-gene and gene-environment interaction effects involving this single-nucleotide polymorphism to AD.

• 出版日期2013-8