A Novel MAPT Mutation Causing Corticobasal Syndrome Led by Progressive Apraxia of Speech

作者：Marshall Charles R; Guerreiro Rita; Thust Steffi; Fletcher Phillip; Rohrer Jonathan D; Fox Nick C^*

来源：Journal of Alzheimer's Disease, 2015, 48(4): 923-926.

DOI：10.3233/JAD-150477

• Corticobasal syndrome
• frontotemporal dementia
• microtubule-associated protein tau
• progressive apraxia of speech

The authors describe a case of corticobasal syndrome led by progressive apraxia of speech, associated with a novel mutation in exon 10 of the MAPT gene. Genetic bases for progressive apraxia of speech and corticobasal syndrome are only rarely described, and have not been described in conjunction.

• 出版日期2015