Does the Size Matter? Prostate Weight Does Not Predict PSA Recurrence After Radical Prostatectomy

作者：Davidson Darrell D; Koch Michael O; Lin Haiqun; Jones Timothy D; Biermann Katharina; Cheng Liang^*

来源：American Journal of Clinical Pathology, 2010, 133(4): 662-668.

DOI：10.1309/APHGXD194SGACJP

• Prostate
• Neoplasm
• Prostate weight
• Radical prostatectomy
• Prostate volume
• Size
• Biochemical recurrence
• Prognosis
• Prostate-specific antigen
• PSA

Previous studies suggest that low prostrate weight is a significant negative prognostic factor for prostate cancer In the current study, the data for 431 men who underwent radical retropubic prostatectomy between 1990 and 1998 were analyzed for association between prostate weight and various clinical and pathologic parameters These included age, preoperative prostate-specific antigen (PSA) level, PSA recurrence, pathologic stage, Gleason grade, extraprostatic extension, positive surgical margins, tumor volume, associated high-grade prostatic intraepithelial neoplasia, perineural invasion, and lymph node metastasis Potenetial associations were probed by using Cox regression model analysis. A significant positive correlation patient age or increasing preoperative PSA level There was no significant independent association between prostate weight and any of the other variables examined No association was found between prostate weight and PSA recurrence Although increasing prostate weight correlates with increased patient age and higher preoperative PSA level, it does not independently predict postoperative cancer recurrence.

• 出版日期2010-4