A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men

作者：Fu Zhenyan; Nakayama Tomohiro^*; Sato Naoyuki; Izumi Yoichi; Kasamaki Yuji; Shindo Atsushi; Ohta Masakatsu; Soma Masayoshi; Aoi Noriko; Sato Mikano; Ozawa Yukio; Ma Yitong; Matsumoto Koichi; Doba Nobutaka; Hinohara Shigeaki

来源：Molecular Genetics and Metabolism, 2009, 96(3): 145-147.

DOI：10.1016/j.ymgme.2008.11.161

• CYP4F2
• Single-nucleotide polymorphism
• Haplotype
• Case-control study
• Gender-specific

This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P=0.006, P=0.001 and P=0.002, respectively).

• 出版日期2009-3
• 单位新疆医科大学