科研之友
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摘要
Global vaccination and gene therapy programs have an urgent demand for stabilization of viral vectors at low temperature. We used a quadramer, a bridge-connected DNA tetra-aptamer to antivesicular stomatitis virus (VSV), as a viral cryoprotectant. Results showed that the tetravalent antivirus DNA aptamers protect viral activity during multiple freezethaw cycles, shield from neutralizing antibodies, and decrease aggregation of viral particles.
- 出版日期2014-11
