Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium

作者：Hollmann Joseph L^*; Horstmeyer Roarke; Yang Changhuei; DiMarzio Charles A

来源：Journal of Biomedical Optics, 2013, 18(2): 025004.

DOI：10.1117/1.JBO.18.2.025004

• ultrasound modulation of light
• guidestar
• turbidity suppression
• finite-difference time-domain
• tissue model

The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling through the US beam waist is frequency shifted and may be isolated with demodulation. This paper utilizes a multiphysics simulation to model the optical and US interactions in both synthetic tissue and random scattering media. The results illustrate that optical energy may be focused within a turbid medium utilizing a US guidestar. The results also suggest that optical energy travels preferentially along optical channels within a turbid medium.

• 出版日期2013-2
• 单位东北大学