An intriguing and facile one-pot catalytic synthesis of N-alkylated lactams

作者：Zoidis Grigoris^*; Naesens Lieve; De Clercq Erik

来源：Monatshefte fur Chemie, 2013, 144(4): 515-521.

DOI：10.1007/s00706-013-0924-8

• One-pot synthesis
• Heterocycles
• Heterogeneous catalysis
• Alkylations
• Antiviral activity
• Bioorganic chemistry

Catalyzed by Raney nickel, hydrogenation of 1,2-adamantane oxime esters or cyano esters afforded the unexpected N-alkylated lactams in good to moderate yields, probably proceeding through the so-called hydrogen autotransfer process. This reaction provided an efficient one-pot method for synthesis of N-alkylated lactams which had significant anti-influenza A activity.

• 出版日期2013-4