Ni-Catalyzed Direct Carboxylation of Benzyl Halides with CO2

作者:Leon Thierry; Correa Arkaitz; Martin Ruben*
来源:Journal of the American Chemical Society, 2013, 135(4): 1221-1224.
DOI:10.1021/ja311045f

摘要

A novel Ni-catalyzed carboxylation of benzyl halides with CO2 has been developed. The described carboxylation reaction proceeds under mild conditions (atmospheric CO, pressure) at room temperature. Unlike other routes for similar means, our method does not require well-defined and sensitive organometallic reagents and thus is a user-friendly and operationally simple protocol for assembling phenylacetic acids.

  • 出版日期2013-1-30