Angiogenesis in rheumatoid arthritis

作者：Szekanecz Zoltan^*; Besenyei Timea; Paragh Gyoergy; Koch Alisa E

来源：Autoimmunity, 2009, 42(7): 563-573.

DOI：10.1080/08916930903143083

• angiogenesis
• rheumatoid arthritis
• vascular endothelial growth factor
• angiostasis therapy

Angiogenesis is the formation of new capillaries from pre-existing vessels. A number of soluble and cell-bound factors may stimulate neovascularization. The perpetuation of angiogenesis involving numerous soluble and cell surface-bound mediators has been associated with rheumatoid arthritis (RA). These angiogenic mediators, among others, include growth factors, primarily vascular endothelial growth factor (VEGF) and hypoxia-inducible factors (HIFs), as well as pro-inflammatory cytokines, various chemokines, matrix components, cell adhesion molecules, proteases and others. Among the several potential angiogenesis inhibitors, targeting of VEGF, HIF-1, angiogenic chemokines, tumor necrosis factor- and the V3 integrin may attenuate the action of angiogenic mediators and thus synovial angiogenesis. In addition, some naturally produced or synthetic compounds including angiostatin, endostatin, paclitaxel, fumagillin analogues, 2-methoxyestradiol and thalidomide may be included in the management of RA.

• 出版日期2009
• 单位河北医科大学