Differential expression of sprouty genes in hepatocellular carcinoma

作者：Sirivatanauksorn Yongyut; Sirivatanauksorn Vorapan^*; Srisawat Chatchawan; Khongmanee Amnart; Tongkham Chalita

来源：Journal of Surgical Oncology, 2012, 105(3): 273-276.

DOI：10.1002/jso.22095

• Sprouty
• SPRY
• hepatocellular carcinoma
• cirrhosis
• angiolymphatic invasion

Background and Objectives Sprouty (Spry) proteins are important modulators of the RTK/Ras/MAPK pathway, overactivation of which is associated with hepatocellular carcinoma (HCC). Thus far, the roles of Sprouty in HCC is still unclear. %26lt;br%26gt;Methods: The expressions of SPRY1, SPRY2, SPRY3, and SPRY4, at the mRNA levels were determined by quantitative RT-PCR in paired HCC and non-tumor liver tissues from 31 patients. %26lt;br%26gt;Results: The expression levels of SPRY1, SPRY2, and SPRY4 in tumor tissues were significantly different from those in non-tumor tissues with the average log fold change values of 0.15, -0.34, and -0.37, respectively; however, that of SPRY3 was not significantly different. SPRY1 expression was also found to be significantly up-regulated in the cases without underlying cirrhosis compared with those with cirrhosis (log fold change of 0.35 and -0.02, respectively, P %26lt; 0.05), whereas SPRY2 expression was significantly lower in the cases with advanced HCC (log fold change of -0.12 and -0.52 in early and advanced stages, respectively, P %26lt; 0.05) and in those with angiolymphatic invasion (log fold change of -0.47 and -0.16 in the presence and absence thereof, P %26lt; 0.05). %26lt;br%26gt;Conclusion: This study demonstrates that Sprouty genes are differentially expressed in HCC and might provide some insight into their roles in HCC carcinogenesis. J. Surg. Oncol. 2012;105:273-276.

• 出版日期2012-3