Dopamine-Based Coatings and Hydrogels: Toward Substitution-Related Structure-Property Relationships

作者：Cui Jiaxi; Iturri Jagoba; Paez Julieta; Shafiq Zahid; Serrano Cristina; d' Ischia Marco; del Campo Arynzazu^*

来源：Macromolecular Chemistry and Physics, 2014, 215(24): 2403-2413.

DOI：10.1002/macp.201400366

• dopamine coatings
• DOPA
• mussel adhesive protein
• polycatechols

The influence of 6-chloro and 6-nitro substituents on the thickness, homogeneity, and general properties of coatings produced by controlled oxidative polymerization of dopamine and its beta-hydroxy derivative, norepinephrine, is investigated. Substitution at the catecholamine 6-position affects the deposition kinetics due to modification of the oxidation potential of the catechol groups. Increasing the hydroxyl group acidity results likewise in changes in pH response and water uptake. A similar trend with pH is also observed in covalently crosslinked catechol-functionalized PEG-hydrogels, while an opposite behavior is measured in metal crosslinked films. These results pave the way toward the definition of structure-property relationships based on dopamine substitution effects in polycatecholamine layers and derived polymers.

• 出版日期2014-12