A New Cytotoxic Clerodane Diterpene from Casearia graveolens Twigs

作者:Meesakul Pornphimol; Ritthiwigrom Thunwadee; Cheenpracha Sarot; Sripisut Tawanun; Maneerat Wisanu; Machan Theeraphan; Laphookhieo Surat*
来源:Natural Product Communications, 2016, 11(1): 13-15.
DOI:10.1177/1934578x1601100105

摘要

The first phytochemical investigation of Casearia graveolens twigs led to the isolation and identification of a new clerodane diterpene, caseariagraveolin (1), together with six known compounds (2-7). Their structures were elucidated by intensive analysis of their spectroscopic data. Compound 1 showed strong cytotoxicity against oral cavity and breast cancer cell lines with IC50 values of 2.48 and 6.63 mu M, respectively.

  • 出版日期2016-1

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