An isocyanide insertion approach to substituted pyrrolo[2,3-b]quinolines under metal-free and azide-free conditions

作者：Liu, Cheng-Guo; Gu, Zheng-Yang; Bai, Hui-Wen; Wang, Shun-Yi^*; Ji, Shun-Jun

来源：Organic Chemistry Frontiers, 2016, 3(10): 1299-1303.

DOI：10.1039/c6qo00373g

• ALKYLIDENECYCLOPROPANES FACILE SYNTHESIS
• POTENT CASPASE-3 INHIBITORS
• ENYNE-CARBODIIMIDES
• GASTRIC (H+/K+)-ATPASE
• OXIDATIVE CYCLIZATION
• REVERSIBLE INHIBITORS
• CATALYZED REACTIONS
• HIGHLY EFFICIENT
• RING ENLARGEMENT
• DERIVATIVES

A new strategy for the catalytic synthesis of the pyrrolo[2,3-b]quinoline skeleton by the reaction of isocyanides with (cyclopropylidene(aryl) methyl) aniline (amino-MCPs) is presented, taking advantage of I-2/CHP mediated carbodiimide intermediate generation. This reaction involves three C-N bonds and one C-C bond generation under metal-free and azide-free conditions.

• 出版日期2016
• 单位苏州大学