Depressive Symptoms and Physical Performance in the Lifestyle Interventions and Independence for Elders Pilot Study

作者：Matthews Margaret M^*; Hsu Fang Chi; Walkup Michael P; Barry Lisa C; Patel Kushang V; Blair Steven N

来源：Journal of the American Geriatrics Society, 2011, 59(3): 495-500.

DOI：10.1111/j.1532-5415.2011.03319.x

• exercise
• physical performance
• depression

OBJECTIVES
To determine whether the presence of high depressive symptoms (Center for Epidemiologic Studies Depression Scale (CES-D) score >= 14) diminished physical performance benefits after a comprehensive physical activity intervention in older adults.
DESIGN
A post hoc analysis of data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study, a single-blind randomized controlled trial comparing a moderate-intensity physical activity intervention (PA) with a successful aging control (SA).
SETTING
Multicenter U.S. institutions participating in the LIFE-P trial.
PARTICIPANTS
Four hundred twenty-four sedentary, noninstitutionalized adults aged 70 to 89.
MEASUREMENTS
Depressive symptoms were assessed using the CES-D. Physical performance tests included the Short Physical Performance Battery (SPPB) and 400-m walk time (400 mw) at baseline and 6 and 12 months.
RESULTS
Of the participants, 15.8% had high depressive symptom scores (CES-D >= 14). For participants with low depressive symptoms, SPPB scores improved more in the PA than the SA group over 12 months (adjusted score difference +0.70; P <.001 at 6 months and +0.58; P=.004 at 12 months), and 400 mw times improved in the PA group at 6 months (adjusted score difference -0.41 minutes; P=.02). For participants with high depressive symptoms, the difference in improvement fell short of statistical significance on the SPPB between the PA and SA groups (adjusted score difference +0.76 (P=.18) at 6 months and +0.94 (P=.12) at 12 months).
CONCLUSION
The presence of high depressive symptoms did not substantially diminish physical performance benefits realized after a PA intervention in sedentary older adults.

• 出版日期2011-3