AROS has a context-dependent effect on SIRT1

作者：Kokkola Tarja^*; Suuronen Tiina; Molnar Ferdinand; Maatta Juha; Salminen Antero; Jarho Elina M; Lahtela Kakkonen Maija

来源：FEBS LETTERS, 2014, 588(9): 1523-1528.

DOI：10.1016/j.febslet.2014.03.020

• AROS
• p53
• Protein-protein interaction
• SIRT1
• Sirtuin

The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging-associated diseases. Active regulator of SIRT1 (AROS) is a small endogenous protein which was originally reported to activate SIRT1 through a direct interaction in cancer cells. We show that the interaction between the two proteins is weak and does not alter the activity of SIRT1 in noncancerous human cells. The results of different in vitro SIRT1 activity assays disclosed AROS as an inhibitor of SIRT1. The functional relationship between AROS and SIRT1 proved to be dependent on the biological context and experimental setting. %26lt;br%26gt;Structured summary of protein interactio

• 出版日期2014-5-2