Unexpected reactivity of trifluoromethylated olefins with indole: a mechanistic investigation

作者：Estevao Monica S; Duarte Filipe J S; Fernandes Eduarda; Gil Santos A; Marques M Manuel B^*

来源：Tetrahedron Letters, 2012, 53(16): 2132-2136.

DOI：10.1016/j.tetlet.2012.02.055

• Trifluoromethyl alkenes
• C-F bond
• Indole
• DFT calculations
• Fluoride elimination

Several trifluoromethylated compounds were reacted with indole sodium salt, leading to monofluorinated compounds. The unexpected products formation was rationalized by DFT calculations.

• 出版日期2012-4-18