Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential

作者：Bardot Evan; Calderon Damelys; Santoriello Francis; Han Songyan; Cheung Kakit; Jadhav Bharati; Burtscher Ingo; Artap Stanley; Jain Rajan; Epstein Jonathan; Lickert Heiko; Gouon Evans Valerie; Sharp Andrew J; Dubois Nicole C

来源：Nature Communications, 2017, 8(1): 14428.

DOI：10.1038/ncomms14428

The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (<5%) of the differentiated heart. These progenitors are specified during gastrulation, when they transiently express Foxa2, a gene not previously implicated in cardiac development. Importantly, Foxa2+ cells contribute to previously identified progenitor populations in a defined pattern and ratio. Lastly, we describe an analogous Foxa2+ population during differentiation of embryonic stem cells. Together, these findings provide insight into the developmental origin of ventricular and atrial cells, and may lead to the establishment of new strategies for generating chamber-specific cell types from pluripotent stem cells.

• 出版日期2017-2-14