A 6-Year-Old Girl With Undiagnosed Hemophagocytic Lymphohistiocytosis and Takotsubo Cardiomyopathy A Case Report and Review of the Literature

作者：Otillio Jaime Kaye^*; Harris Jeffrey K; Tuuri Rachel

来源：Pediatric Emergency Care, 2014, 30(8): 561-565.

DOI：10.1097/PEC.0000000000000189

• shock
• hemophagocytic lymphohistiocytosis
• HLH
• takotsubo
• cardiomyopathy

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of highly stimulated immune responses to antigens that leads to life-threatening inflammation and multiple organ dysfunction. At presentation, HLH may uncommonly mimic septic shock. In this case, we present a 6-year-old girl presenting to the pediatric emergency department with a febrile illness and anemia that subsequently developed decompensated shock, initially thought to be septic. She was ultimately diagnosed with HLH. During initial HLH treatment, this patient also developed takotsubo cardiomyopathy, a unique pattern of reversible left ventricular dysfunction characterized by transient apical ballooning and hypokenesis of the left ventricle that spontaneously resolves. There are very few case reports of HLH-associated takotsubo cardiomyopathy. We believe that this is the first case of takotsubo cardiomyopathy in a child with HLH.

• 出版日期2014-8