Dual C-H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach

作者：Min Chang; Sanchawala Abbas; Seidel Daniel^*

来源：Organic Letters, 2014, 16(10): 2756-2759.

DOI：10.1021/ol501073f

Iminium ions generated in situ via copper(I) bromide catalyzed oxidation of N-aryl amines readily undergo [4 + 2] cycloadditions with a range of dienophiles. This method involves the functionalization of both a C(sp(3))-H and a C(sp(2))-H bond and enables the rapid construction of polycyclic amines under relatively mild conditions.

• 出版日期2014-5-16
• 单位rutgers