Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

作者：Donohue Kathleen M; Hoffman Eric A; Baumhauer Heather; Guo Junfeng; Ahmed Firas S; Lovasi Gina S; Jacobs David R Jr; Enright Paul; Barr R Graham^*

来源：Journal of Allergy and Clinical Immunology, 2013, 131(2): 361-+.

DOI：10.1016/j.jaci.2012.11.036

• Airway remodeling
• airway structure
• asthma
• emphysema
• epidemiology

Background: The potential consequences of asthma in childhood and young adulthood on lung structure in older adults have not been studied in a large, population-based cohort. %26lt;br%26gt;Objective: The authors hypothesized that a history of asthma onset in childhood (age 18 years or before) or young adulthood (age 19-45 years) was associated with altered lung structure on computed tomography in later life. %26lt;br%26gt;Methods: The Multi-Ethnic Study of Atherosclerosis Lung Study recruited 3965 participants and assessed asthma history by using standardized questionnaires, guideline-based spirometry, and segmental airway dimensions and percentage of low attenuation area (%LAA) on computed tomographic scans. %26lt;br%26gt;Results: Asthma with onset in childhood and young adulthood was associated with large decrements in FEV1 among participants with a mean age of 66 years (-365 mL and -343 mL, respectively; P%26lt;.001). Asthma with onset in childhood and young adulthood was associated with increased mean airway wall thickness standardized to an internal perimeter of 10 mm (0.1 mm, P%26lt;.001 for both), predominantly from narrower segmental airway lumens (-0.39 mm and -0.34 mm, respectively; P%26lt;.001). Asthma with onset in childhood and young adulthood also was associated with a greater %LAA (1.69% and 4.30%, respectively; P%26lt;.001). Findings were similar among never smokers, except that differential %LAA in childhood-onset asthma were not seen in them. %26lt;br%26gt;Conclusion: Asthma with onset in childhood or young adulthood was associated with reduced lung function, narrower airways, and among asthmatic patients who smoked, greater %LAA in later life. (J Allergy Clin Immunol 2013;131:361-8.)

• 出版日期2013-2