Application of silver nanoparticles to the chemiluminescence determination of cefditoren pivoxil using the luminol-ferricyanide system

作者：Alarfaj Nawal A; Aly Fatma A; El Tohamy Maha F^*

来源：Luminescence, 2015, 30(1): 91-97.

DOI：10.1002/bio.2696

• silver nanoparticles
• cefditoren pivoxil
• luminol-ferricyanide system
• sequential injection analysis
• chemiluminescence

A new simple, accurate and sensitive sequential injection analysis chemiluminescence (CL) detection method for the determination of cefditoren pivoxil (CTP) has been developed. The developed method was based on the enhancement effect of silver nanoparticles on the CL signal arising from a luminol-potassium ferricyanide reaction in the presence of CTP. The optimum conditions relevant to the effect of luminol, potassium ferricyanide and silver nanoparticle concentrations were investigated. The proposed method showed linear relationships between relative CL intensity and the investigated drug concentration at the range 0.001-5000ng/mL, (r=0.9998, n=12) with a detection limit of 0.5pg/mL and quantification limit of 0.001ng/mL. The relative standard deviation was 1.6%. The proposed method was employed for the determination of CTP in bulk drug, in its pharmaceutical dosage forms and biological fluids such as human serum and urine. The interference of some common additive compounds such as glucose, lactose, starch, talc and magnesium stearate was investigated. In addition, the interference of some related cephalosporins was tested. No interference was recorded. The obtained sequential injection analysis-CL results were statistically compared with those from a reported method and did not show any significant differences.

• 出版日期2015-2