A novel synthesis of functionalized 1,1-difluoro-1-alkenes via isolable 2,2-difluorovinylsilanes

作者：Ichikawa J^*; Ishibashi Y; Fukui H

来源：Tetrahedron Letters, 2003, 44(4): 707-710.

DOI：10.1016/S0040-4039(02)02652-7

• alkenes
• fluorine and compounds
• silicon and compounds
• substitution

Various 1,1-difluoro-1-alkenes such as monosubstituted 1,1-difluoro-1-alkenes, 2-bromo-1,1-difluoro-1-alkenes, and 1,1-difluoro-3-hydroxy-1-alkenes are prepared in two simple steps from 1-trifluoromethylvinylsilane: (i) its S(N)2' reaction with nucleophiles to construct 2.2-difluorovinylsilanes and (ii) the subsequent substitution of electrophiles for the vinylic silyl group.

• 出版日期2003-1-20