Angiogenic markers in canine lymphoma tissues do not predict survival times in chemotherapy treated dogs

作者：Wolfe**erger B^*; Tonar Z; Fuchs Baumgartinger A; Walter I; Skalicky M; Witter K; Thalhammer J G; Pagitz M; Kleiter M

来源：Research in Veterinary Science, 2012, 92(3): 444-450.

DOI：10.1016/j.rvsc.2011.04.018

• Canine lymphoma
• Vascular endothelial growth factor
• Receptors
• Microvessel density
• Overall survival time

Angiogenesis, which is essential for malignancies to progress, depends on various signalling proteins including vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors 1 and 2 (VEGFR-1 and VEGFR-2). Microvessel density (MVD) is frequently used to evaluate angiogenesis. This study assessed the relationship between expression of VEGF, VEGFR-1 and VEGFR-2, MVD and the survival time in dogs with lymphoma. VEGF, VEGFR-1 and VEGFR-2 expression was evaluated immunohistochemically and microvessel profiles were counted in 34 lymphoma samples. Seventy-nine percent of the samples showed high VEGF expression and 62% were highly positive for VEGFR-1; VEGFR-2 immunoreactivity was mostly negative. Dogs treated with chemotherapy had a median survival time of 266 days, but no significant relationships were found between overall survival time, MVD and expression of VEGF, VEGFR-1 or VEGFR-2. In this study, VEGF its receptors and the MVD were no prognostic factors in dogs with lymphoma.

• 出版日期2012-6