Lactobacillus plantarum HY7712 Protects Against the Impairment of NK-Cell Activity Caused by Whole-Body gamma-Irradiation in Mice

作者：Lee Hoyong; Ahn Young Tae; Park Se Hoon; Park Do Young; Jin Young Woo; Kim Cha Soon; Sung Sang Hyun; Huh Chul Sung; Kim Dong Hyun^*

来源：Journal of Microbiology and Biotechnology, 2014, 24(1): 127-131.

DOI：10.4014/jmb.1307.07001

• Lactobacillus plantarum HY7712
• gamma-irradiation
• aging
• NK cell activity

While searching for lactic acid bacteria that can restore aging-impaired immune responses, we isolated the Toll-like receptor (TLR) 2/NF-kappa B-activating strain Lactobacillus plantarum HY7712 from kimchi and investigated its immunomodulating effect in whole-body gamma-irradiated mice. Exposure to HY7712 strongly activated NF-kappa B signaling in RAW264.7 cells, but inhibited lipopolysaccharide-stimulated NF-kappa B activation. Moreover, HY7712 protected against the downregulation of interferon (IFN)-gamma and upregulation of interleukin (IL)-13 caused by gamma-irradiation in mice. In mice, gamma-irradiation impaired NK-cell activity against YAC-1 tumor cells, but following HY7712 exposure, the activity of NK cells was restored to 91.5% of the level measured in control mice (p < 0.05). These findings suggest that HY7712 activates the TLR2/NF-kappa B signaling pathway and protects against the impairment of NK-cell activity caused by gamma-irradiation or aging.

• 出版日期2014-1