Detection of pancreatic adenocarcinoma using circulating fragments of fibrinogen

作者：Ward Douglas G; Wei Wenbin; Buckels John; Taha Ahmed M I; Hegab Bassem; Tariciotti Laura; Salih Rasha; Qi Yi Qun; Martin Ashley; Johnson Philip J^*

来源：European Journal of Gastroenterology and Hepatology, 2010, 22(11): 1358-1363.

DOI：10.1097/MEG.0b013e32833b6d41

• biomarker
• cancer
• fibrinogen
• pancreas
• proteomics

Background There is an urgent need for biomarkers to detect pancreatic cancer in the early, potentially curable, stages.
Methods We have used SELDI profiling to analyze serum from 75 patients with pancreatic cancer and 61 patients with nonmalignant pancreaticobiliary diseases.
Results A peak in the SELDI spectra corresponding to a 53 residue fragment of the alpha-chain of fibrinogen is remarkably elevated in approximately 50% of the cancer patients. In addition, fibrinogen degradation products were measured using the DR-70 assay. The areas under the receiver operating characteristic curves for the SELDI-detected fibrinogen fragment, DR-70 and CA19-9 were 0.65, 0.75 and 0.86, respectively. Class prediction models using combinations of these markers did not increase the area under the receiver operating characteristic curve compared with CA19-9. The novel fibrinogen fragment was not elevated to the same extent in other malignancies but was elevated in some patients with benign pancreatic disease.
Conclusion Both the SELDI-detected fragment of fibrinogen and DR-70 are significantly elevated in the serum of pancreatic cancer patients. However, they do not seem to improve pancreatic cancer detection over CA19-9 alone.

• 出版日期2010-11