New Chromone and Triglyceride from Cucumis melo Seeds

作者：Ibrahim Sabrin R M^*

来源：Natural Product Communications, 2014, 9(2): 205-208.

DOI：10.1177/1934578x1400900217

• Chromone
• Triglyceride
• Cucumis melo
• Cucurbitaceae
• Cytotoxicity
• Antioxidant

Re-investigation of the MeOH extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) led to the isolation of a new chromone derivative (5,7-dihydroxy-2-[2-(3-methoxy-4-hydroxyphenyl)ethyl]chromone (5) and a triglyceride (1,3-di-(6Z,9Z)-docosa-6,9-dienoyl-2-(6Z) hexacos-6-enoylglycerol (1), together with three known compounds; alpha-spinasterol (2), stigmasta-7,22,25-trien-3-ol (3), and D:B-friedoolean-5-ene-3-beta-ol (4), are reported from this species for the first time. Their structures were determined by extensive 1D (H-1, C-13, and DEPT) and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR and mass spectral measurements. Compound 5 displayed significant cytotoxic activity against L5178Y cells, with an ED50 of 5 mu M. The MeOH extract and 5 showed antioxidant activity using the DPPH assay.

• 出版日期2014-2