Diverse alkaloid-like structures from a common building block

作者：Goff Dane A^*

来源：Tetrahedron, 2013, 69(1): 242-256.

DOI：10.1016/j.tet.2012.10.038

• Diversity oriented synthesis
• Alkaloid-like molecule
• Nitromethyl group

A wealth of unique enantiopure polycyclic alkaloid-like scaffolds can be prepared on a multigram scale in only a few steps from a common, commercially available intermediate. The attached nitromethyl group can then be used to construct highly diverse functionalized libraries suitable for screening against biological targets of interest.

• 出版日期2013-1-7