An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions

作者:Tsai Yi Ling; Fan Yu Shiou; Lee Chia Jui; Huang Chan Hui; Das Utpal; Lin Wenwei*
来源:Chemical Communications, 2013, 49(87): 10266-10268.
DOI:10.1039/c3cc45883k

摘要

Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.

  • 出版日期2013