mTOR at the crossroads of T cell proliferation and tolerance

作者：Mondino Anna; Mueller Daniel L^*

来源：Seminars in Immunology, 2007, 19(3): 162-172.

DOI：10.1016/j.smim.2007.02.008

• anergy
• proliferation
• CD4+T cells
• mTOR

Several events control the activation, proliferation, and the continued Ag responsiveness of naive and memory T lymphocytes. Here we review the individual contributions of TCR, CD28, and IL-2-driven signaling to T cell proliferation and anergy avoidance. The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed.

• 出版日期2007-6