A low glycaemic diet improves oral glucose tolerance but has no effect on beta-cell function in C57BL/6J mice

作者：Andersson U^*; Rosen L; Wierup N; Ostman E; Bjorck I; Holm C

来源：Diabetes, Obesity and Metabolism, 2010, 12(11): 976-982.

DOI：10.1111/j.1463-1326.2010.01288.x

• beta-cell
• body composition
• glycaemic control

Aim: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model.
Methods: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance.
Results: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat content ameliorates the negative effect of a high glycaemic diet. No effect on body weight or body fat content was observed in either a low-fat diet or a medium-fat diet. Static incubation of isolated islets did not show any differences in basal (3.3 mM glucose) or glucose-stimulated (8.6 and 16.7 mM glucose) insulin secretion between mice fed a low or high glycaemic diet.
Conclusion: Together, our data suggest that the impaired glucose tolerance seen after a high glycaemic diet is not explained by altered beta-cell function.

• 出版日期2010-11