Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y l)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

Van der Plas Steven E; Kelgtermans Hans; De Munck Tom; Martina Sebastien L X; Dropsit Sebastien; Quinton Evelyne; De Blieck Ann; Joannesse Caroline; Tomaskovic Linda; Jans Mia; Christophe Thierry; van der Aar Ellen; Borgonovi Monica; Nelles Luc; Gees Maarten; Stouten Pieter; Van Der Schueren Jan; Mammoliti Oscar; Conrath Katja; Andrews Martin

doi:10.1021/acs.jmedchem.7b01288

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Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-y l)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

作者：Van der Plas Steven E; Kelgtermans Hans; De Munck Tom; Martina Sebastien L X; Dropsit Sebastien; Quinton Evelyne; De Blieck Ann; Joannesse Caroline; Tomaskovic Linda; Jans Mia; Christophe Thierry; van der Aar Ellen; Borgonovi Monica; Nelles Luc; Gees Maarten; Stouten Pieter; Van Der Schueren Jan; Mammoliti Oscar; Conrath Katja; Andrews Martin

来源：Journal of Medicinal Chemistry, 2018, 61(4): 1425-1435.

DOI：10.1021/acs.jmedchem.7b01288