Acyl derivatives of boswellic acids as inhibitors of NF-kappa B and STATs

作者：Kumar Ajay; Shah Bhahwal A^*; Singh Samar; Hamid Abid; Singh Shashank K; Sethi Vijay K; Saxena Ajit K; Singh Jaswant; Taneja Subhash C

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(1): 431-435.

DOI：10.1016/j.bmcl.2011.10.112

• Boswellic acids
• Acyl derivatives
• Anti-cancer
• NF-kappa B
• STAT

Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-kappa B and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.

• 出版日期2012-1-1