Association of plasma and synovial fluid interferon-gamma inducible protein-10 with radiographic severity in knee osteoarthritis

作者：Saetan Natthaphon; Honsawek Sittisak^*; Tanavalee Aree; Tantavisut Saran; Yuktanandana Pongsak; Parkpian Vinai

来源：Clinical Biochemistry, 2011, 44(14-15): 1218-1222.

DOI：10.1016/j.clinbiochem.2011.07.010

• Disease severity
• Interferon-gamma inducible protein-10
• Osteoarthritis
• Plasma
• Synovial fluid

Objectives: The objective of this study was to investigate interferon-gamma inducible protein-10 (IP-10) concentrations in plasma and synovial fluid of patients with knee osteoarthritis (OA) and to analyze their relationship with disease severity.
Design and methods: Forty OA patients and 15 healthy controls were enrolled in this study. OA grading was performed according to the Kellgren-Lawrence criteria. IP-10 levels in plasma and synovial fluid were assessed using enzyme-linked immunosorbent assay.
Results: Plasma IP-10 levels in the knee OA patients were significantly lower than those of controls (P=0.006). IP-10 levels in plasma were markedly higher with regard to paired synovial fluid (P<0.001). Furthermore, IP-10 concentrations in plasma and synovial fluid displayed significant inverse correlation with radiographic severity (r = -0.713, P<0.001 and r = -0.561, P<0.001, respectively). Subsequent analysis revealed that plasma IP-10 levels were positively correlated with synovial fluid IP-10 levels (r = 0.424, P = 0.006).
Conclusions: IP-10 levels in both plasma and synovial fluid were inversely associated with the severity of knee OA. Accordingly, IP-10 could serve as a biomarker for determining disease severity and might play a possible role in the pathophysiology of osteoarthritis.

• 出版日期2011-10