科研之友
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摘要
A series of 3'-methyl-branched and purine-modified analogues of aristeromycin were synthesized via the SN(2) displacement of a key triflate, which was prepared from a readily available enantiopure building block in eight steps. The synthesized compounds were evaluated as potential antiviral agents against important viruses. Only the 2,6-diaminopurine derivative exhibited moderate activity against vesicular stomatitis virus.
- 出版日期2008-10-17
- 单位河北医科大学
