Fast intra-axonal transport: Beginning, development and post-genome advances

作者：Dahlstrom Annica B^*

来源：Progress in Neurobiology, 2010, 90(2): 119-145.

DOI：10.1016/j.pneurobio.2009.11.004

• Intra-axonal transport
• Fast and slow transport
• Anterograde and retrograde transport
• Falck-Hillarp fluorescence histochemistry
• Fluorescence immunohistochemistry
• Biochemical assays
• Cytofluorimetric scanning
• Retrograde transport
• Molecular motors
• Defects in axonal transport and neurodegenerative diseases

The review describes the initial experiments suggesting a fast intra-axonal transport of transmitter related substances, in addition to the "classic" slow flow. Early experiments were mainly conducted in the peripheral adrenergic system, focusing on transport of amine storage granules, the extent of the vast sympathetic adrenergic system and the importance of axonal transport of amine granules for the adrenergic system. Further, it describes important advances obtained from studies of other neuron systems regarding local axonal protein synthesis, motor proteins and new insights regarding relation between faults in the transport machinery and some neuropathological conditions.

• 出版日期2010-2-9