A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolino-fused Spiro[pyrazolo[3,4-b]pyridine-indolines]

作者：Gupta Sunil K; Arya Anand K; Khandelwal Sarita; Kumar Mahendra^*

来源：Current Organic Chemistry, 2014, 18(19): 2555-2560.

DOI：10.2174/138527281819141028114753

• Multicomponent domino reaction
• spirooxindole
• pyrazolo[3,4-b]pyridine
• pyrazolochromenopyridine
• pyrazolopyranopyridine
• pyrazoloquinolinopyridine

An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4-b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic beta-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.

• 出版日期2014