A folding algorithm for extended RNA secondary structures

作者：Siederdissen Christian Hoener Zu^*; Bernhart Stephan H; Stadler Peter F; Hofacker Ivo L

来源：Bioinformatics, 2011, 27(13): I129-I136.

DOI：10.1093/bioinformatics/btr220

Motivation: RNA secondary structure contains many non-canonical base pairs of different pair families. Successful prediction of these structural features leads to improved secondary structures with applications in tertiary structure prediction and simultaneous folding and alignment.
Results: We present a theoretical model capturing both RNA pair families and extended secondary structure motifs with shared nucleotides using 2-diagrams. We accompany this model with a number of programs for parameter optimization and structure prediction.

• 出版日期2011-7-1
• 单位上海生物信息技术研究中心