An automated synthesizer for electrochemical F-18-fluorination of organic compounds

作者：Waldmann Christopher M; Lebedev Artem; Allison Nathaniel; Sadeghi Saman^*

来源：Applied Radiation and Isotopes, 2017, 127: 245-252.

DOI：10.1016/j.apradiso.2017.06.028

• Electrochemistry
• [F-18]fluoride
• Radiosynthesizer
• Late-stage fluorination
• PET

Electrochemical F-18-fluorination of organic compounds provides a means to synthesize Positron-Emission Tomography (PET) tracers difficult to obtain otherwise. Here, the first automated synthesizer that enables radiolabeling through carrier-added electrochemical F-18-fluorination is described. The system provides capabilities for all necessary operations such as drying of cyclotron derived [F-18] fluoride, electrochemical incorporation of the radioisotope into a precursor molecule, subsequent reactions such as protecting group removals, HPLC-purification and formulation of the final tracer. Demonstrated is the aliphatic electrochemical F-18 fluorination of methyl 2-(phenylthio)acetate.

• 出版日期2017-9