Non-Hodgkin lymphoma expressing high levels of the danger-signalling protein HMGB1

作者：Meyer Anke; Staratschek Jox Andrea; Springwald Anette; Wenk Heiner; Wolf Juergen; Wickenhauser Claudia; Bullerdiek Joern^*

来源：Leukemia and Lymphoma, 2008, 49(6): 1184-1189.

DOI：10.1080/10428190802064909

• non-Hodgkin lymphoma
• HMGB1
• quantitative real-time RT-PCR
• angiogenesis

HMGB1 is a high mobility group protein that can act either as a DNA binding protein or extracellularly as a cytokine-like danger signal. Extracellular HMGB1, either actively secreted or passively released by necrotic cells, is linked to inflammation and cancer. Herein, the results of a study to quantify the expression of HMGB1 in lymphomas by quantitative real-time RTPCR are presented. HMGB1 expression was analysed in 18 non-Hodgkin lymphomas and two lymphoma cell lines. 11/18 primary lymphomas expressed HMGB1 mRNA at a level exceeding the average of normal lymph nodes. Immunohistochemistry showed that HMGB1 positivity is confined to the lymphoma cells. No correlation between HMGB1 expression and grading was found. However, a high percentage of lymphomas is overexpressing a danger-signalling protein. This protein can support the growth and angiogenesis of lymphoma cells in a paracrine way when released e. g. due to necrosis. Thus it constitutes an interesting therapeutic target as well.

• 出版日期2008