Axonal Degeneration: RIPK1 Multitasking in ALS

作者:Politi Kristin; Przedborski Serge*
来源:Current Biology, 2016, 26(20): R932-R934.
DOI:10.1016/j.cub.2016.08.052

摘要

A recent study reports that microglia and oligodendrocytes promote motor neuron degeneration by inducing inflammation and necroptosis in a manner dependent on receptor-interacting kinase 1 (RIPK1). These findings could be significant for our understanding of the neurobiology and treatment of neurodegenerative diseases like amyotrophic lateral sclerosis.

  • 出版日期2016-10-24