Dehydroepiandrosterone induces growth arrest of hepatoma cells via alteration of mitochondrial gene expression and function

作者：Ho Hung Yao^*; Cheng Mei Ling; Chiu Hsin Yu; Weng Shiue Fen; Chiu Daniel Tsun Yee

来源：International Journal of Oncology, 2008, 33(5): 969-977.

DOI：10.3892/ijo_00000084

• steroid
• hepatoma
• mitochondrion

DHEA is known to have anti-proliferative effect. The mechanism is not completely understood. We investigated the mechanism underlying DHEA-induced growth arrest of hepatoma cells. Growth inhibition was associated with increased G6PD activity, and insensitive to reversal by mevalonate. Thus, DHEA does not act via inhibition of G6PD and HMGR. Instead, growth stagnation was accompanied by reduced expression of nucleus-encoded mitochondrial genes; morphological and functional alterations of mitochondria; and depletion of intracellular ATP. Conversely, pyruvate supplementation alleviated DHEA-induced growth inhibition. It is likely that DHEA suppresses cell growth by altering mitochondrial gene expression, morphology and functions.

• 出版日期2008-11
• 单位河北医科大学; 长春大学