A facile strategy to prepare porphyrin functionalized ZnS nanoparticles and their peroxidase-like catalytic activity for colorimetric sensor of hydrogen peroxide and glucose

作者：Liu, Qingyun^*; Chen, Pengpeng; Xu, Zhe; Chen, Miaomiao; Ding, Yanan; Yue, Kang; Xu, Jian

来源：Sensors and Actuators B: Chemical , 2017, 251: 339-348.

DOI：10.1016/j.snb.2017.05.069

• H2TCPP
• ZnS
• Nanocomposite
• Peroxidase
• H2O2
• Glucose

In this article, we demonstrated a facile method to prepare the porphyrin [5,10,15,20-Tetrakis (4-carboxyl phenyl) porphyrin] functionalized ZnS nanoparticles (H2TCPP-ZnS nanocomposites) under the mild conditions. Porphyrin molecules serves as both a functional molecule and stabilizer. TEM images showed that H2TCPP-ZnS nanocomposites are composed of nanoparticles with ca. 5-8 nm in size. The nanocomposites were for the first time developed as a peroxidase mimetic with catalytic activities and could catalyze the colorimetric reaction of H2O2 and 3,3',5,5' -tetramethylbenzidine (TMB), where the oxidized TMB showed a typical absorption peak at 652 nm. Kinetic analysis indicated that the catalytic behavior was in accordance with typical Michaelis-Menten kinetics. Moreover, H2TCPP-ZnS nanocomposites could accelerate H2O2 to decompose into OH radicals. The intrinsic peroxidase-like activity of H2TCPP-ZnS nanocomposites is due to the synergistic effect of H2TCPP as well as ZnS in the nanocomposites. Based on these findings, a simple and sensitive colorimetric assay to detect H2O2 and glucose with a range of concentration from 0.01 to 0.06 mM and from 0.005 to 0.5 mM, respectively. In addition, this nanosensor can also be used for glucose detection in diluted serum.

• 出版日期2017-11
• 单位山东科技大学; 青岛大学