A Scalable, Chromatography-Free Synthesis of Benzotetramisole

Daniels David S B; Smith Siobhan R; Lebl Tomas; Shapland Peter; Smith Andrew D<sup>*</sup>

doi:10.1055/s-0034-1378931

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A Scalable, Chromatography-Free Synthesis of Benzotetramisole

作者：Daniels David S B; Smith Siobhan R; Lebl Tomas; Shapland Peter; Smith Andrew D^*

来源：Synthesis, 2015, 47(1): 34-41.

DOI：10.1055/s-0034-1378931

摘要

The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.