Antiretroviral Therapy in HIV-Infected Elite Controllers: Impact on Gut Immunology, Microbial Translocation, and Biomarkers of Serious Non-AIDS Conditions

作者：Kim Connie J; Kovacs Colin; Chun Tae Wook; Kandel Gabor; O**orne Brendan J W; Huibner Sanja; Shahabi Kamnoosh; Yue Feng Yun; Benko Erika; Ostowski Mario; Kaul Rupert^*

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2014, 67(5): 514-518.

• HIV
• elite controllers
• antiretroviral therapy
• gut immunology
• microbial translocation
• serious non-AIDS conditions
• inflammation

Elite controllers (ECs) maintain undetectable HIV viral loads without antiretroviral therapy (ART) but are at increased risk of serious non-AIDS conditions (SNA). We assessed the impact of ART in ECs on gut immune dysfunction and biomarkers predicting SNA (blood CD4/CD8 ratio, plasma IL-6, D-dimer levels). At baseline, ECs had elevated IL-6 and D-dimer levels and reduced CD4/CD8 ratio compared with HIV-uninfected controls, but no difference in microbial translocation or gut CD4 subsets. ART increased CD4/CD8 ratio but did not normalize IL-6 and D-dimer levels. EC SNA pathogenesis may be independent of gut immune dysfunction, and resolution may require prolonged ART.

• 出版日期2014-12-5