An Efficient Synthesis and Biological Testing of Novel 3-Chloro-4-aryl-1-(4-(phenyldiazenyl)phenyl)azetidin-2-ones

作者:Chopde Himani N; Pagadala Ramakanth; Meshram Jyotsna S*; Jetti Venkateshwarlu
来源:Journal of Heterocyclic Chemistry, 2010, 47(6): 1361-1366.
DOI:10.1002/jhet.459

摘要

N-Benzylidene-4-(phenyldiazenyl)aniline (Ia-Ij) has been prepared from p-aminoazobenzene with different aromatic aldehydes under microwave irradiation, which on further treatment with chloro acetic acid and POCl3 in the presence of triethyl amine gave the title compounds. The structure of the compounds has been confirmed by spectroscopic techniques (IR and H-1 NMR) and elemental analysis. These azetidinones analogues were screened for their antimicrobial activities against strains of different microorganisms. Some of the compounds displayed the promising antibacterial activities against some bacterial strains.

  • 出版日期2010-11