Direct measurement of lung motion using hyperpolarized helium-3 MR tagging

作者：Cai Jing; Miller G Wilson; Altes Talissa A; Read Paul W; Benedict Stanley H; De lange Eduard E; Cates Gordon D; Brookeman James R; Mugler John P III; Sheng Ke^*

来源：International Journal of Radiation Oncology, Biology, Physics, 2007, 68(3): 650-653.

DOI：10.1016/j.ijrobp.2007.02.011

• lung motion
• deformable registration
• hyperpolarized helium-3
• MR tagging.

Purpose: To measure lung motion between end-inhalation and end-exhalation using a hyperpolarized helium-3 (HP He-3 magnetic resonance (MR) tagging technique.
Methods and Materials: Three healthy volunteers underwent MR tagging studies after inhalation of 1 L Hp 3He gas diluted with nitrogen. Multiple-slice two-dimensional and volumetric three-dimensional MR tagged images of the lungs were obtained at end-inhalation and end-exhalation, and displacement vector maps were computed.
Results: The grids of tag lines in the Hp 3He MR images were well defined at end-inhalation and remained evident at end-exhalation. Displacement vector maps clearly demonstrated the regional lung motion and deformation that occurred during exhalation. Discontinuity and differences in motion pattern between two adjacent lung lobes were readily resolved.
Conclusions: Hyperpolarized helium-3 MR tagging technique can be used for direct in vivo measurement of respiratory lung motion on a regional basis. This technique may lend new insights into the regional pulmonary biomechanics and thus provide valuable information for the deformable registration of lung.

• 出版日期2007-7-1