Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma

作者：Roveri Maurizio; Pfohl Alice; Jaaks Patricia; Alijaj Nagjie; Leroux Jean Christophe; Luciani Paola; Bernasconi Michele

来源：Nanomedicine, 2017, 12(10): 1135-1151.

DOI：10.2217/nnm-2016-0430

• biodistribution
• furin
• liposomes
• peptide
• pharmacokinetic
• rhabdomyosarcoma
• targeting
• vincristine

Aim: Our goal was to improve vincristine (VCR) based rhabdomyosarcoma (RMS) therapy by encapsulating the drug into liposomes. A targeting strategy was attempted to enhance tumor accumulation. Materials & methods: VCR was loaded in control and peptide-decorated liposomes via an active method. The interaction of an RMS-specific peptide with the presumed target furin and the cellular uptake of both liposomal groups were studied in vitro. Pharmacokinetics and biodistribution of VCR-containing liposomes were assessed in an RMS xenograft mouse model. Results: Liposomes ensured high VCR concentration in plasma and in the tumor. Peptide-decorated liposomes showed modest uptake in RMS cells. Conclusion: The investigated peptide-modified liposomal formulation may not be optimal for furin-mediated RMS targeting. Nevertheless, VCR-loaded liposomes could serve as a delivery platform for experimental RMS.

• 出版日期2017-5