An exploration of the surgical modality of sentinel lymph node biopsy in patients with cN0 tongue carcinoma: An animal study

作者：Liu, Xia-Cheng; Yang, Wen-Jun; Zhang, Chen-Ping^*; Qu, Xing-Zhou; Wang, Tao; Qiu, Li-Hua; Ji, Ping

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2011, 112(4): 439-445.

DOI：10.1016/j.tripleo.2010.11.008

• SQUAMOUS-CELL CARCINOMA
• METHYLENE-BLUE DYE
• NECK-CANCER
• ISOSULFAN BLUE
• BREAST-CANCER
• MUCOSAL HEAD
• ORAL TONGUE
• LOCALIZATION
• MELANOMA
• GROWTH

Objective. Lymphatic mapping with vital dye is often exploited during a sentinel lymph node biopsy (SLNB); however, the time restraints associated with blue dye may limit its efficacy in tongue carcinoma. Using an animal study, this exploration attempted to achieve a rational surgical modality to circumvent this hindrance. @@@ Study design. Forty-eight rabbits were divided into 2 equal groups: A and B; 0.2 mL methylene blue (MB) was injected into 4 parts of the tongues of the rabbits in A just after elevating the cervical flap and into the tongues of the rabbits in B just before the elevation. The times when the lymphatic vessel and lymph node turned blue and then returned pale were recorded. @@@ Results. Cases in group A had significantly more time left for tracing blue-stained lymphatic vessels than those in group B. @@@ Conclusions. Elevating the cervical flap before injecting MB can alleviate the time restraint of MB as a lymphatic tracer in SLNB with tongue carcinoma. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: 439-445)

• 出版日期2011-10
• 单位上海交通大学; 重庆医科大学