Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus

作者：Lee Sun Hee; Park Wan Beom; Lee Shinwon; Park Sohee; Kim Shin Woo; Lee Jong Myung; Chang Hyun Ha; Kwon Ki Tae; Choe Pyoeng Gyun; Kim Nam Joong; Bin Kim Hong; Oh Myoung Don

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(11): 6928-6932.

DOI：10.1128/AAC.01517-16

Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 mu/ml for the Ser-Cys group and 40.32 mu/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.

• 出版日期2016-11