A meta-analysis on the association between three promoter variants of TNF-alpha and Crohn's disease

作者：Xie, Cui; Liu, Xiao Feng; Yang, Mao Sheng^*

来源：Molecular Biology Reports, 2012, 39(2): 1575-1583.

DOI：10.1007/s11033-011-0896-x

• TNF-alpha
• Crohn's disease
• Susceptibility
• Meta-analysis

Tumor necrosis factor-alpha (TNF-alpha) has been regarded as a candidate gene for Crohn's disease (CD) based on its inflammatory function in immune reaction and the clinical effectiveness of anti-TNF-alpha therapy. However, studies to date have reported inconsistent findings for the association between TNF-alpha and CD. The PubMed, EM-BASE, and Medline databases were systematically reviewed from all English language publications up to April, 2011. A total of twenty-nine studies concerning the association between CD and the TNF-alpha promoter polymorphisms of -308G/A, -857C/T and -238G/A were identified, among of them only twenty-three studies match the inclusion criteria (including 3,843 cases and 6,260 controls) and were selected for the statistical test. We found that neither the G allele of -308G/A (OR 1.02, 95% CI 0.87-1.19, P = 0.84), C allele of -857C/T (OR 0.97, 95% CI 0.86-1.09, P = 0.57) and G allele of -238G/A (OR 0.91, 95% CI 0.70-1.18, P = 0.48), and nor their GG (OR 1.05, 95% CI 0.88-1.25, P = 0.59), CC (OR 0.98, 95% CI 0.86-1.12, P = 0.76) and GG (OR 0.92, 95% CI 0.70-1.21, P = 0.55) genotypes were associated with CD susceptibility, respectively. Our meta-analysis demonstrates that three promoter polymorphisms of TNF-alpha above may not confer susceptibility to CD.

• 出版日期2012-2
• 单位重庆医科大学